'lack of moral shame and dread', 

are two of the 4 unwholesome factors associated with all karmically unwholesome states of consciousness, the two others being restlessness (uddhacca) and delusion (moha). Cf. Tab. II.

"There are two sinister things, namely, lack of moral shame and dread, etc." (A.II.6). "Not to be ashamed of what one should be ashamed of; not to be ashamed of evil, unwholesome things: this is called lack of moral shame" (Pug. 59). "Not to dread what one should dread ... this is called lack of moral dread (Pug. 60).